PHLPP1 Produkte
(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
Kategorien
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
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Ausgewählte PHLPP1 Kategorien
PHLPP1 Antikörper
High quality antibodies with extensive validation data.
Empfohlene PHLPP1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN6145573
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7130610
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6264947
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PHLPP1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6206653
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PHLPP1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
- (1)
Kat. Nr.
ABIN2728848
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PHLPP1 Produkten
: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." in: Carcinogenesis, (2018) (PubMed).: "Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
: "Interactome of the negative regulator of nuclear import BRCA1-binding protein 2." in: Scientific reports, Vol. 5, pp. 9459, (2015) (PubMed).
: "Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1." in: Science signaling, Vol. 6, Issue 267, pp. ra19, (2013) (PubMed).
: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." in: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).
: "mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6510-20, (2011) (PubMed).
: "Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein ..." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19777-88, (2011) (PubMed).
: "Cell-type-specific regulation of raft-associated Akt signaling." in: Cell death & disease, Vol. 2, pp. e145, (2011) (PubMed).
: "IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects." in: Endocrinology, Vol. 151, Issue 8, pp. 3752-63, (2010) (PubMed).
: "Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN ..." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27900-10, (2010) (PubMed).
Synonyme und alternative Namen zu PHLPP1
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), PH domain and leucine rich repeat protein phosphatase 1 (phlpp1), PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), AI836256, mKIAA0606, PHLPP, Phlpp, PLEKHE1, Plekhe1, SCOP, ScopBezeichner auf Proteinebene für PHLPP1
- PH domain and leucine rich repeat protein phosphatase 1
- PH domain leucine-rich repeat-containing protein phosphatase 1-like
- PH domain leucine-rich repeat-containing protein phosphatase 1
- PH domain-containing family E member 1
- SCN circadian oscillatory protein
- pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
- suprachiasmatic nucleus circadian oscillatory protein
- pleckstrin homology domain-containing family E member 1
- Circadian Oscillatory Protein (SCOP)
- PH domain leucine-rich repeat protein phosphatase 1
- pleckstrin homology domain-containing family E protein 1
Haben Sie etwas anderes gesucht?
- PHLDB3
- PHLDB2
- PHLDB1
- PHLDA3
- PHLDA2
- PHLDA1
- PHKG2
- PHKG1
- PHKB
- PHKA2
- PHKA1
- PHIP
- PHGR1
- PHGDH
- PHF8
- PHF7
- PHF6
- PHF5A
- PHF3
- PHF23
- PHLPP2
- PHNC2
- PHO85
- Phosducin
- Phosducin-Like
- Phosphatase and Actin Regulator 3
- Phosphatase and Actin Regulator 4
- Phosphatase and Tensin Homolog
- Phosphate Cytidylyltransferase 1, Choline, alpha
- Phosphate Cytidylyltransferase 1, Choline, beta
- Phosphate-Binding Protein PstS 1
- Phosphatidylinositol Antibody IgG/IgM
- Phosphatidylinositol Binding clathrin Assembly Protein
- Phosphatidylinositol Phosphate
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta
- Phospho Protein Kinase C
- Phospho-Extracellular Signal-Regulated Kinase
- PHOSPHO1
- PHOSPHO2
- Phosphodiesterase
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