PHLPP2 Produkte
(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
Kategorien
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
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Ausgewählte PHLPP2 Kategorien
PHLPP2 Antikörper
High quality antibodies with extensive validation data.
PHLPP2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PHLPP2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), FACS
Validierungen
- (3)
Kat. Nr.
ABIN652395
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC, IHC (p), IP
Validierungen
- (2)
Kat. Nr.
ABIN962593
Menge
50 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (1)
Kat. Nr.
ABIN392229
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene PHLPP2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6212123
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PHLPP2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124383
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3094545
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3136302
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PHLPP2 Produkten
: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." in: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).
: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
Synonyme und alternative Namen zu PHLPP2
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2), PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S), PH domain and leucine rich repeat protein phosphatase 2 (phlpp2), PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), AI481772, C130044A18Rik, PHLPPL, phlppl, Phlppl, RGD1562857Bezeichner auf Proteinebene für PHLPP2
- PH domain leucine-rich repeat-containing protein phosphatase 2
- PH domain and leucine rich repeat protein phosphatase 2
- PH domain leucine-rich repeat-containing protein phosphatase 2-like
- GTPase activating protein and VPS9 domains 1
Haben Sie etwas anderes gesucht?
- PHLPP1
- PHLDB3
- PHLDB2
- PHLDB1
- PHLDA3
- PHLDA2
- PHLDA1
- PHKG2
- PHKG1
- PHKB
- PHKA2
- PHKA1
- PHIP
- PHGR1
- PHGDH
- PHF8
- PHF7
- PHF6
- PHF5A
- PHF3
- PHNC2
- PHO85
- Phosducin
- Phosducin-Like
- Phosphatase and Actin Regulator 3
- Phosphatase and Actin Regulator 4
- Phosphatase and Tensin Homolog
- Phosphate Cytidylyltransferase 1, Choline, alpha
- Phosphate Cytidylyltransferase 1, Choline, beta
- Phosphate-Binding Protein PstS 1
- Phosphatidylinositol Antibody IgG/IgM
- Phosphatidylinositol Binding clathrin Assembly Protein
- Phosphatidylinositol Phosphate
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta
- Phospho Protein Kinase C
- Phospho-Extracellular Signal-Regulated Kinase
- PHOSPHO1
- PHOSPHO2
- Phosphodiesterase
- Phosphodiesterase I
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