PHLPP1 Protein (Myc-DYKDDDDK Tag)
-
- Target Alle PHLPP1 Produkte
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- Protein-Typ
- Recombinant
- Spezies
- Human
- Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses PHLPP1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
-
- Recombinant human PHLPP1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
-
- Applikationshinweise
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
-
The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
-
Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." in: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).
: "
-
Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
-
- Target
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- Andere Bezeichnung
- Phlpp1 (PHLPP1 Produkte)
- Synonyme
- PHLPP Protein, PLEKHE1 Protein, SCOP Protein, AI836256 Protein, Phlpp Protein, Plekhe1 Protein, mKIAA0606 Protein, Scop Protein, PH domain and leucine rich repeat protein phosphatase 1 Protein, PHLPP1 Protein, phlpp1 Protein, Phlpp1 Protein
- Hintergrund
- This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
- Molekulargewicht
- 184.5 kDa
- NCBI Accession
- NP_919431
- Pathways
- PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung
-