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PDE4C Produkte

(phosphodiesterase 4C, CAMP-Specific (PDE4C))

Kategorien

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

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Ausgewählte PDE4C Kategorien

PDE4C Antikörper

High quality antibodies with extensive validation data.

PDE4C Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PDE4C Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF
Validierungen
  • (3)
Kat. Nr. ABIN518723
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IF, IHC, ICC
Validierungen
  • (3)
Kat. Nr. ABIN6259147
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA
Validierungen
  • (2)
Kat. Nr. ABIN518724
Menge 200 μL
Datenblatt Datenblatt

Empfohlene PDE4C ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6231743
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PDE4C Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1314466
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3085804
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3121999
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PDE4C Produkten

Cheng, Wu, He, Liu, Jia, Di, Ji: "siRNA-mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin-stimulated primary cultured microglia." in: Experimental and therapeutic medicine, Vol. 12, Issue 4, pp. 2257-2264, (2017) (PubMed).

Ji, Di, He, Liu, Liu, Li, Zhang: "Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1914-22, (2016) (PubMed).

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Yougbaré, Boire, Roy, Lugnier, Rouseau: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

Murray, Patel, Suda, Zhang, Thistlethwaite, Yuan, Insel: "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 1, pp. L294-303, (2007) (PubMed).

Gallagher, Bacon, Odumeru, Gallagher, Fitzpatrick, Regan: "Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression." in: Neurotoxicology and teratology, Vol. 26, Issue 1, pp. 73-81, (2004) (PubMed).

Synonyme und alternative Namen zu PDE4C

phosphodiesterase 4C (PDE4C), phosphodiesterase 4C, cAMP-specific a (pde4ca), phosphodiesterase 4C (pde4c), phosphodiesterase 4C, cAMP specific (Pde4c), phosphodiesterase 4C (Pde4c), dpde1, Dpde1, DPDE1, dunce, E130301F19Rik, im:7160317, pde4c, PDE4C, si:dkey-149i17.5

Bezeichner auf Proteinebene für PDE4C

  • cAMP-specific 3',5'-cyclic phosphodiesterase 4C
  • phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
  • Pde43
  • phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog)
  • PDE21
  • phosphodiesterase E1 dunce homolog
  • cAMP-specific 35-cyclic phosphodiesterase 4C
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