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Guinea Pig Monoclonal NR3C1 Primary Antibody für BP, ChIP - ABIN268501
Lambert, Nordeen: CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. in Molecular endocrinology (Baltimore, Md.) 2003
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Human Monoclonal NR3C1 Primary Antibody für WB - ABIN1882199
Wang, Shen, Thiyagarajan, Lin, Palm, Horvath, Klopstock, Cutler, Pique, Schrijver, Davis, Mindrinos, Speed, Scharfe: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. in Nucleic acids research 2011
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Human Monoclonal NR3C1 Primary Antibody für BI, IF - ABIN968431
Beato, Herrlich, Schütz: Steroid hormone receptors: many actors in search of a plot. in Cell 1996
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Human Monoclonal NR3C1 Primary Antibody für BI, IF - ABIN968430
Hollenberg, Weinberger, Ong, Cerelli, Oro, Lebo, Thompson, Rosenfeld, Evans: Primary structure and expression of a functional human glucocorticoid receptor cDNA. in Nature 1986
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Human Monoclonal NR3C1 Primary Antibody für ICC, FACS - ABIN969321
Charmandari, Ichijo, Jubiz, Baid, Zachman, Chrousos, Kino: A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. in The Journal of clinical endocrinology and metabolism 2008
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Human Monoclonal NR3C1 Primary Antibody für ELISA, WB - ABIN2473809
Harris, Kerns, St Clair: RNA sulfurtransferase activity in rat liver and chemically induced hepatomas. in Cancer research 1976
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Cow (Bovine) Polyclonal NR3C1 Primary Antibody für ChIP, ICC - ABIN152763
He, Simons: STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. in Molecular and cellular biology 2007
Human Polyclonal NR3C1 Primary Antibody für IF (p), IHC (p) - ABIN685138
Ding, Shi, Han, Cui: Regulation of glucocorticoid-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction filial rats. in Life sciences 2016
Human Polyclonal NR3C1 Primary Antibody für ChIP, ICC - ABIN152786
Liang, Kowalczyk, Junco, Klug-De Santiago, Malik, Wei, Slaga: Differential effects on lung cancer cell proliferation by agonists of glucocorticoid and PPARα receptors. in Molecular carcinogenesis 2014
Opn4m2 (zeige OPN4 Antikörper) labeling shows nuclear localization, which did not change in response to light. opn4m1 (zeige OPN4 Antikörper), opn4m2 (zeige OPN4 Antikörper), gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts
Data (including data from studies in knockout/transgenic mice) suggest that, under hypoxic conditions, muscle atrophy and elevated gene expression of ubiquitin proteasomal system-associated enzymes are mostly independent of glucocorticoid/Nr3c1 signaling.
We propose that the GC-induced mitochondrial accumulation of Bax (zeige BAX Antikörper) and the interaction between the GR and Bim (zeige BCL2L11 Antikörper), Bcl-xL (zeige BCL2L1 Antikörper) and Bak (zeige BAK1 Antikörper) could play a role in the regulation of thymocyte apoptosis.
The potentiation of RANKL (zeige TNFSF11 Antikörper) induced CTX release by dexamethasone was significantly less in bone marrow macrophage cells from mice with conditional knockout of the osteoclastic glucocorticoid receptor and completely absent in cells from GR(dim) mice, which carry a point mutation in one dimerizing interface of the GC receptor.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (zeige HSP90 Antikörper) cochaperone activity of FKBP51 (zeige FKBP5 Antikörper) with a functional impact on GR signaling in a neuronal context.
These results together suggested that ERK1 (zeige MAPK3 Antikörper) phosphorylation plays a critical role in regulating GR beta expression and hydrocortisone-induce GR phosphorylation at Ser220, which is critical for the anti-apoptotic effects hydrocortisone on hepatic ischemia-reperfusion injury.
a significant protein-protein interaction between GR and CHOP (zeige DDIT3 Antikörper), (GR-CHOP (zeige DDIT3 Antikörper) heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (zeige PPARA Antikörper) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (zeige CDK5R1 Antikörper); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (zeige CDK5R1 Antikörper)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (zeige HSP90 Antikörper)-p23 (zeige CDK5R1 Antikörper) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (zeige NR1D1 Antikörper) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (zeige HSP90AA2 Antikörper) and HSP90beta (zeige HSP90AB1 Antikörper), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (zeige PRKAA1 Antikörper) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (zeige PPARA Antikörper) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (zeige HSP90 Antikörper) complex that favor FKBP51 (zeige FKBP5 Antikörper) repression over FKBP52 (zeige FKBP4 Antikörper) potentiation.
A Tri (zeige VANGL2 Antikörper)-Nucleotide Pattern in a 3' UTR (zeige UTS2R Antikörper) Segment Affects The Activity of a Human Glucocorticoid Receptor Isoform
Association Between N363S and BclI Polymorphisms of the Glucocorticoid Receptor Gene (NR3C1) and Glucocorticoid Side Effects During Childhood Acute Lymphoblastic Leukemia Treatment.
genetic association studies in population in Brazil: Data suggest that an SNP in NR3C1 (A3669G) is associated with appetite regulation and food preferences; here, adolescents carrying A3669G variant exhibited decreased comfort food intake.
Results provide evidence for an association between the NR3C1-rs41423247 SNP and depression: C minor allele of rs41423247 increased depressive symptoms during early abstinence of women with crack cocaine addiction, but it did not have effects over detoxification treatment. A slight effect of CC genotype was shown at late abstinence phase. C allele of this SNP was associated to an increased number of rehospitalizations.
There was no significant interaction between NR3C1 and stressful life events with respect to alcohol use/misuse.
Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 (zeige SFRS9 Antikörper) and SRSF3 (zeige SRSF3 Antikörper) in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA.
Association between suicide and altered NR3C1 gene expression in the prefrontal cortex.
Results identified three novel heterozygous missense NR3C1 mutations causing glucocorticoid resistance in patients with adrenal incidentalomas without Cushing's syndrome. p.R477S and p.Y478C are located in the DNA binding domain (DBD) of the glucocorticoid receptor (GR) while p.L67P is located in the ligand binding domain of GR.
Data show that the 3' UTR (zeige UTS2R Antikörper) of glucocorticoid receptor beta (GRbeta) is regulated by miR144.
Except for a slightly higher risk of bronchopulmonary dysplasia (BPD (zeige MOD(MDG4) Antikörper)) in carriers of the GRBclI variant, the glucocorticoid receptor gene polymorphisms BclI, N363S, and R23K did not affect neonatal outcome parameters in this large multicenter cohort of Very-Low-Birth-Weight preterm infants.
These results indicate that myostatin (zeige MSTN Antikörper) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (zeige FOXO3 Antikörper) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (zeige TP53 Antikörper) and specificity protein 1 (Sp1 (zeige SP1 Antikörper)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Antikörper) and PTGS2 (zeige PTGS2 Antikörper), and decreased the expression of SOD2 (zeige SOD2 Antikörper), GPX3 (zeige GPX3 Antikörper), DAB2 (zeige DAB2 Antikörper), and NR3C1. TNF (zeige TNF Antikörper) and IL6 (zeige IL6 Antikörper) levels were also decreased while those of NAMPT (zeige NAMPT Antikörper) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (zeige HSD11B2 Antikörper) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (zeige GARS Antikörper), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma