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Thus, we concluded that fine-tuning expression of Bcl-3 is needed for proper CD4 (zeige CD4 Antikörper)(+) T-cell development and is required to sustain Th17-cell mediated pathology.
Bcl-3 suppressed colorectal tumor formation: Bcl-3-deficient mice were relatively protected from DSS (zeige PMP22 Antikörper)-induced epithelial damage and developed more polyps after AOM (zeige COL2A1 Antikörper)/DSS (zeige PMP22 Antikörper) treatment, although polyp size was unaffected.
this study implicates the intracellular protein (zeige CKAP2 Antikörper), BCL3, as a key mediator of the IL-10 (zeige IL10 Antikörper)-induced immunosuppressive macrophage phenotype
These results establish that Bcl3 positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 as a downstream molecule of LIF (zeige LIF Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling in pluripotency maintenance.
Bcl3 reduces the inflammatory response in pancreas/biliary tissue by blocking ubiquitination and proteasome-mediated degradation of nuclear factor-kappaB p50 (zeige NFKB1 Antikörper) homodimers.
Low expression of IL-6 (zeige IL6 Antikörper) and TNF-alpha (zeige TNF Antikörper) correlates with the presence of the nuclear regulators of NF-kappaB (zeige NFKB1 Antikörper), IkappaBNS (zeige NFKBID Antikörper) and BCL-3, in the uterus of mice.
These findings demonstrate that Bcl-3 is required in dendritic cells to prime protective T-cell-mediated immunity to T. gondii
data show that BCL-3 makes extensive contacts with p50 (zeige LSP1 Antikörper) homodimers and in particular with ankyrin (zeige ANK Antikörper) repeats (ANK) 1 (zeige ANK1 Antikörper), 6, and 7, and the N-terminal region of Bcl-3.
The presence of a p50 (zeige LSP1 Antikörper)/Bcl-3 complex in nuclear extracts from cells of metastatic lung tissues.
In SOD1 (zeige SOD1 Antikörper) and Neurotomized mice the results of this studysuggest LC3 (zeige MAP1LC3A Antikörper), Fn14 (zeige TNFRSF12A Antikörper), Bcl3 and Gadd45a (zeige GADD45A Antikörper) as candidate genes involved in the maintenance of the severe atrophic state.
B-cell leukemia protein 3 (zeige HSPB3 Antikörper) (Bcl3) expressed in response to cytokine TWEAK (zeige TNFSF12 Antikörper) stimulation (experimental kidney injury) decreases TWEAK (zeige TNFSF12 Antikörper)-induced inflammatory and lethal responses.
Four gene signature (PTEN, PIK3C2A (zeige PIK3C2A Antikörper), ITPA (zeige ITPA Antikörper) and BCL3) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma (zeige MOK Antikörper).
Akt2 (zeige AKT2 Antikörper), Erk2 (zeige MAPK1 Antikörper), and IKK1 (zeige CHUK Antikörper)/2 phosphorylate Bcl3, converting Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA.
Bcl-3 knockdown enhanced the degradation of Smad3 (zeige SMAD3 Antikörper) but not Smad2 (zeige SMAD2 Antikörper) following TGFbeta (zeige TGFB1 Antikörper) treatment.
We have shown for the first time that BCL-3 promotes the growth of colorectal cancer cells through activation of the AKT (zeige AKT1 Antikörper) pathway, increasing tumour cell yield both in vitro and in vivo.
BCL3 serves as an oncogene (zeige RAB1A Antikörper) in glioma by modulating proliferation, cell cycle progression and apoptosis, and its oncogenic effects are mediated by the STAT3 (zeige STAT3 Antikörper) signaling pathway.
miR (zeige MLXIP Antikörper)-19b silencing promoted cell proliferation and cell cycle progression in gastric cancer cells and BCL3 was identified as a direct target of miR (zeige MLXIP Antikörper)-19b
Study confirmed that BCL-3 is overexpressed in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) tissues and correlated with adverse clinicopathological features and poorer prognosis. BCL-3 can promote the growth of HCC (zeige FAM126A Antikörper) cells by promoting cell viability, proliferation and cell cycle progression through regulation of CCND1 (zeige CCND1 Antikörper) expression.
Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
B-cell CLL/lymphoma 3
, B-cell leukemia/lymphoma 3
, B-cell lymphoma 3 protein homolog
, B-cell lymphoma 3 protein
, B-cell lymphoma 3-encoded protein
, chronic lymphatic leukemia protein
, proto-oncogene BCL3