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anti-PDGFRB (PDGFRB) Antikörper

Bezeichnung:: anti-Platelet-Derived Growth Factor Receptor, beta Polypeptide Antikörper (PDGFRB)

Auf www.antikoerper-online.de finden Sie aktuell 518 Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Antikörper von 36 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PDGFRB Kits (56) und PDGFRB Proteine (44) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 660 PDGFRB Produkte verfügbar.

Synonyme:: AI528809, CD140B, IBGC4, JTK12, PDGFR, PDGFR-1, PDGFR1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	PDGFRB	18596	P05622
	PDGFRB	24629	Q05030
	PDGFRB	5159	P09619
Alle Spezies anzeigen Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-PDGFRB (PDGFRB) Antikörper

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anti-Mouse (Murine) PDGFRB Antikörper:

anti-Rat (Rattus) PDGFRB Antikörper:

anti-Human PDGFRB Antikörper:

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Verknüpfte Pathways mit anti-PDGFRB Antikörper

Platelet-derived growth Factor Receptor Signaling

Weitere Produktkategorien zu PDGFRB Antikörper

Am meisten referenzierte anti-PDGFRB Antikörper

Human Polyclonal PDGFRB Primary Antibody für CyTOF, FACS - ABIN4900243 : Campbell, Allen, Silversides, Trimble et al.: Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell ... in Diabetes 2003 (PubMed)
Show all 16 Pubmed References
Human Monoclonal PDGFRB Primary Antibody für FACS, IHC - ABIN4900877 : Nagineni, Kutty, Detrick, Hooks: Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. in Journal of cellular physiology 2005 (PubMed)
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Human Monoclonal PDGFRB Primary Antibody für FACS - ABIN4898828 : Frassanito, Rao, Moschetta, Ria, Di Marzo, De Luisi, Racanelli, Catacchio, Berardi, Basile, Menu, Ruggieri, Nico, Ribatti, Fumarulo, Dammacco, Vanderkerken, Vacca: Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies. in Leukemia 2014 (PubMed)
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Human Polyclonal PDGFRB Primary Antibody für IF, IHC - ABIN6713336 : Wang, Liu, Zhao, Jiang, Luo, Wang, Yin: Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways. in Molecular and cellular endocrinology 2014 (PubMed)
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Human Monoclonal PDGFRB Primary Antibody für ELISA, WB - ABIN966814 : Hansen, Rönnstrand, Rorsman, Hellman, Heldin: Association of coatomer proteins with the beta-receptor for platelet-derived growth factor. in Biochemical and biophysical research communications 1997 (PubMed)
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Human Polyclonal PDGFRB Primary Antibody für IHC (p), ELISA - ABIN544333 : Whiteman, Chen, Birnbaum: Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates. in Endocrinology 2003 (PubMed)
Show all 3 Pubmed References
Human Monoclonal PDGFRB Primary Antibody für FACS - ABIN2688973 : Ebert, Kasper, Hernberg, Friess, Büchler, Roessner, Korc, Malfertheiner: Overexpression of platelet-derived growth factor (PDGF) B chain and type beta PDGF receptor in human chronic pancreatitis. in Digestive diseases and sciences 1998 (PubMed)
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Human Monoclonal PDGFRB Primary Antibody für ELISA, WB - ABIN969346 : Wilczynski, Chen, Chen, Howell, Shively, Alberts: Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. in Human pathology 2005 (PubMed)
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Human Monoclonal PDGFRB Primary Antibody für FACS - ABIN4898826 : Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012 (PubMed)
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Human Monoclonal PDGFRB Primary Antibody für ICS - ABIN1177131 : Claesson-Welsh: Platelet-derived growth factor receptor signals. in The Journal of biological chemistry 1995 (PubMed)
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Weitere Antikörper gegen PDGFRB Interaktionspartner

Mouse (Murine) Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Interaktionspartner

the tyrosine phosphatase Shp-2 to be the master regulator of Pdgfr phosphotyrosine signaling.
PDGFR signaling is necessary for postnatal tendon growth and remodeling and MT1-MMP is a critical mediator of tendon fibroblast migration.
PDGFR alpha beta and PDGFR beta beta dimers were strong inducers of random and directionally-persistent migration in mouse skin fibroblast, respectively, that was sustained for up to 24 h.
PDGFRbeta was activated around the injury site after experimental traumatic brain injury (TBI), and primarily expressed in astrocytes, microglia, OPC and leukocytes in the boundary of the lesion site, suggesting PDGFRbeta was involved in glial scar formation. Then the PDGFR inhibitor (AG1296) was administered following TBI. Reactive astrocytes were significantly inhibited in AG1296-treated mice.
Increasing the adipogenic capacity of Pdgfrbeta(+) precursors through Pparg overexpression results in healthy visceral white adipose tissue expansion in obesity and adiponectin-dependent improvements in glucose homeostasis.
PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
The data of this study revealed an acute accumulation of PDGFRbeta+ BBB-related cells in degenerating brain areas, which can be long lasting, suggesting an active role for PDGFRbeta-signaling in blood vessel and post-injury tissue recovery.
Ltbp4 regulates Pdgfrb expression via TGFbeta-dependent modulation of Nrf2 transcription factor function.
Beta platelet-derived growth factor is induced in hepatic stellate cells (HSCs) following surgical partial hepatectomy, and its deletion in HSCs leads to prolonged liver injury in mice. However, there is no significant difference in liver regeneration.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.
Identify PDGFRbeta as a driver in activating Akt/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.
Data show that three platelet-derived growth factor receptor beta (PDGFRB) mutants (R561C, P660T and N666K) were able to transform NIH3T3 and Ba/F3 cells to different extents.
data therefore collectively suggest that upon TGFbeta stimulation, SP1 recruits SMAD2 to the promoter of Pdgfrb to up-regulate its expression and thus Pdgfrb is a direct downstream target of the TGFbeta/SMAD2 signaling
PdgfrbetaF7/F7 mice between 4-6 and 36-48 weeks of age developed a region-dependent loss in pericyte coverage (22-46, 24-44 and 4-31%) and cell numbers (36-49, 34-64 and 11-36%), reduction in capillary length (20-39, 13-46 and 1-30%), and an increase in extravascular fibrinogen-derived deposits (3.4-5.2, 2.8-4.1 and 0-3.6-fold) demonstrating BBB breakdown in the cortex, hippocampus and thalamus, respectively.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
there is great possibility that EPCs overexpressing PDGFR-beta enhanc VSMC apoptosis and suppress VSMC migration by competitive consumption of PDGF-BB in the early phase after carotid artery injury in mice.
PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.
The results from this study indicate that PDGF signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.
Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR) downregulation and reciprocal epidermal growth factor receptor (EGFR) upregulation.
Decreased expression of PDGFR-beta in vascular smooth muscle cells was associated with thrombosis in vivo.

Human Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Interaktionspartner

The hypomethylated gene, NRP1, and its co-expressed gene, PDGFRB, were significantly correlated with tumor malignant phenotypes.
The CD146 regulates PDGF-B/PDGFRbeta signaling in a multifaceted manner, involving CD146-PDGFRbeta binding, CD146 dimerization, PI3K recruitment, and CD146-cytoskeleton binding.
These findings reveal a novel regulatory role of JAK2-mediated PDGFRbeta proteolysis in triple negative breast cancer
we describe a complex clonal evolution pattern in Ph-like ALL and identified a novel PDGFRB point mutation that drives leukemia relapse after ABL TKI treatment.
Our study confirms that PDGFRB mutation carriers in general have a mild clinical phenotype, and basal ganglia calcifications can be detected by a CT scan, also in asymptomatic mutation carriers
In the nucleus, PDGFRbeta formed ligand-inducible complexes with the tyrosine kinase Fer and its substrate, TATA element-modifying factor 1 (TMF-1).
Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia.
Protein expression of tumour and/or stromal cell PDGFRalpha, PDGFRbeta and PDGF-CC was evaluated in primary tumours (N = 489), synchronous lymph node metastases (N = 135) and asynchronous recurrences (N = 39) using immunohistochemistry in a prospectively maintained cohort of primary breast cancer patients
Case Reports: PDGFRB mutation in premature ageing syndrome, Penttinen type.
EBF1-PDGFRB is sufficient to drive leukemogenesis.
Study demonstrated that LRIG2 promoted the PDGFRBinduced proliferation of glioblastoma multiforme cells in vitro and in vivo through regulating the PDGFRB signalingmediated cell cycle progression.
High expression of PDGFR-beta in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence.
Study investigated the more detailed mechanism for this cis-interaction of Necl-5 with the PDGF receptor beta. Necl-5 contains three Ig-like domains and the PDGF receptor beta contains five Ig-like domains at their extracellular regions; showed that the third Ig-like domain of Necl-5 cis-interacted with the fifth Ig-like domain of the PDGF receptor beta.
Study revealed that high PDGFRbeta expression in cancer tissue was an independent marker of poor prognosis relating to recurrence in patients with colorectal cancer.
Melatonin reinforces the anticancer activity of sorafenib by downregulation of PDGFR-beta/STAT3 signaling pathway and melatonin receptor (MT)-mediated STAT3.
High GLI2 or PDGFRB expression is associated with unfavorable survival in GC patients. GLI2 can induce PDGFRB expression in GC cells via directly binding to its promoter. In addition, the GLI2-PDGFRB axis might be an important signaling pathway modulating CSC properties of GC cells.
The cell surface PDGFRB is a major link between high glucose and its effectors Hif1a and TGFB for induction of diabetic mesangial cell hypertrophy.
describes three unique PDGFRB fusions in childhood B- or T-ALL. All three PDGFRB fusion partners have previously been reported to be implicated in hematopoiesis and immune responses
These findings indicated that miR-518b may function as a tumor suppressor by targeting PDGFRB in the occurrence and development of GBM.
Data show that an equilibrium mixture of two unusual end-insertion G-quadruplexes forms in a native promoter sequence and appears to be the molecular recognition for platelet derived growth factor receptor beta (PDGFR-beta) downregulation.

PDGFRB Antigen-Profil

Beschreibung des Gens

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor\; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Alternative names and synonyms associated with PDGFRB

platelet derived growth factor receptor, beta polypeptide (Pdgfrb) Antikörper
platelet derived growth factor receptor beta (Pdgfrb) Antikörper
platelet derived growth factor receptor beta (PDGFRB) Antikörper

AI528809 Antikörper
CD140B Antikörper
IBGC4 Antikörper
JTK12 Antikörper
PDGFR Antikörper
PDGFR-1 Antikörper
PDGFR1 Antikörper

Bezeichner auf Proteinebene für PDGFRB

CD140 antigen-like family member B , PDGF beta chain , PDGF-R-beta , PDGFR-beta , beta platelet-derived growth factor receptor , beta-type platelet-derived growth factor receptor , platelet-derived growth factor receptor 1 , platelet-derived growth factor receptor beta , platelet-derived growth factor receptor beta variant 1 , Platelet-derived growth factor receptor, beta , protein tyrosin kinase

GENE ID	SPEZIES
18596	Mus musculus
24629	Rattus norvegicus
5159	Homo sapiens
442985	Canis lupus familiaris
770488	Gallus gallus
100342872	Oryctolagus cuniculus

Ausgewählte Anbieter für anti-PDGFRB (PDGFRB) Antikörper

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Show all anti-Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Antikörper with Pubmed References

Mouse (Murine) Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Interaktionspartner

Human Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with PDGFRB

Bezeichner auf Proteinebene für PDGFRB