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PDGFRB Antikörper (Platelet Derived Growth Factor Receptor beta) AA 981-1066 Primary Antibody

PDGFRB Reaktivität: Human, Maus, Ratte ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN726635
$352.31
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 4 bis 6 Werktagen
  • Target Alle PDGFRB Antikörper anzeigen
    PDGFRB
    Bindungsspezifität
    • 22
    • 22
    • 22
    • 16
    • 14
    • 11
    • 9
    • 9
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 981-1066
    Reaktivität
    • 216
    • 92
    • 83
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 196
    • 29
    • 3
    • 2
    Kaninchen
    Klonalität
    • 186
    • 44
    Polyklonal
    Konjugat
    • 118
    • 14
    • 9
    • 9
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Dieser PDGFRB Antikörper ist unkonjugiert
    Applikation
    • 136
    • 90
    • 64
    • 53
    • 52
    • 30
    • 30
    • 23
    • 15
    • 11
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Homologie
    Dog,Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PDGF-R-B
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PDGFRB
    Andere Bezeichnung
    PDGF Receptor beta (PDGFRB Produkte)
    Synonyme
    AI528809, CD140b, PDGFR-1, Pdgfr, CD140B, IBGC4, JTK12, PDGFR, PDGFR1, platelet derived growth factor receptor, beta polypeptide, platelet derived growth factor receptor beta, Pdgfrb, PDGFRB
    Hintergrund

    Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades, the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases.

    Subcellular location: Cell membrane

    Synonyms: IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1, Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFRB

    Gen-ID
    5159
    UniProt
    P09619
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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