CD40 Antikörper

Produktnummer ABIN969025

Produktdetails anti-CD40 Antikörper

Target: CD40

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD40 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC)

Verwendungszweck: CD40 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of CD40 expressed in E. Coli.

Klon: 9G10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-CD40 Antikörper (ABIN969025)

Linderoth, Jerkeman, Cavallin-Ståhl, Kvaløy, Torlakovic: "Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B-cell lymphoma: a Nordic Lymphoma Group Study." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 722-8, (2003) (PubMed).

Hakkarainen, Hemminki, Pereboev, Barker, Asiedu, Strong, Kanerva, Wahlfors, Curiel: "CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 619-24, (2003) (PubMed).

Details zu CD40

Target: CD40

Andere Bezeichnung: CD40 (CD40 Produkte)

Hintergrund: CD40 Molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molekulargewicht: 30.6 kDa

Gen-ID: 958

UniProt: P25942

Pathways: NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints