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CD40 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD40 in ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN969025

Kurzübersicht für CD40 Antikörper (ABIN969025)

Target

Alle CD40 Antikörper anzeigen
CD40

Reaktivität

  • 226
  • 135
  • 27
  • 19
  • 8
  • 6
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 142
  • 108
  • 69
  • 8
  • 4
  • 4
  • 2
  • 2
Maus

Klonalität

  • 234
  • 96
  • 7
Monoklonal

Konjugat

  • 159
  • 30
  • 25
  • 19
  • 16
  • 7
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD40 Antikörper ist unkonjugiert

Applikation

  • 210
  • 105
  • 77
  • 65
  • 48
  • 34
  • 33
  • 22
  • 22
  • 16
  • 14
  • 13
  • 11
  • 8
  • 6
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
ELISA, Immunocytochemistry (ICC)

Klon

9G10
  • Verwendungszweck

    CD40 Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of CD40 expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Linderoth, Jerkeman, Cavallin-Ståhl, Kvaløy, Torlakovic: "Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B-cell lymphoma: a Nordic Lymphoma Group Study." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 722-8, (2003) (PubMed).

    Hakkarainen, Hemminki, Pereboev, Barker, Asiedu, Strong, Kanerva, Wahlfors, Curiel: "CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 619-24, (2003) (PubMed).

  • Target

    CD40

    Andere Bezeichnung

    CD40

    Hintergrund

    CD40 Molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

    Molekulargewicht

    30.6 kDa

    Gen-ID

    958

    UniProt

    P25942

    Pathways

    NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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