TLR9 Antikörper (N-Term)

Produktnummer ABIN967190

Der Kaninchen Polyklonal Anti-TLR9-Antikörper wurde für IHC validiert. Er ist geeignet, TLR9 in Proben von Maus zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für TLR9 Antikörper (N-Term) (ABIN967190)

Target: TLR9 (Toll-Like Receptor 9 (TLR9))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR9 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-TLR9 Antikörper

Bindungsspezifität: N-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse Tlr9 (Toll-like receptor 9)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-TLR9 Antikörper (ABIN967190)

Kiyokawa, Akashi-Takamura, Shibata, Matsumoto, Nishitani, Kuroki, Seto, Miyake: "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors." in: International immunology, Vol. 20, Issue 11, pp. 1407-15, (2008) (PubMed).

Tabeta, Georgel, Janssen, Du, Hoebe, Crozat, Mudd, Shamel, Sovath, Goode, Alexopoulou, Flavell, Beutler: "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3516-21, (2004) (PubMed).

Chuang, Lee, Kline, Mathison, Ulevitch: "Toll-like receptor 9 mediates CpG-DNA signaling." in: Journal of leukocyte biology, Vol. 71, Issue 3, pp. 538-44, (2002) (PubMed).

Bauer, Kirschning, Häcker, Redecke, Hausmann, Akira, Wagner, Lipford: "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9237-42, (2001) (PubMed).

Details zu TLR9

Target: TLR9 (Toll-Like Receptor 9 (TLR9))

Andere Bezeichnung: Tlr9

Hintergrund: Tlr9 (Toll-like receptor 9) participates in the innate immune response to microbial agents. Tlr9 (Toll-like receptor 9) detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Tlr9 (Toll-like receptor 9) plays a role in defense against sytemic mouse cytomegalovirus infection. Tlr9 (Toll-like receptor 9) binds MYD88 via their respective TIR domains and interacts with CNPY3. Tlr9 (Toll-like receptor 9) belongs to the Toll-like receptor family and contains 26 LRR (leucine-rich) repeats and 1 TIR domain.

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades