Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

TDG Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TDG in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 4+ Publikationen erwähnt.
Produktnummer ABIN967162

Kurzübersicht für TDG Antikörper (C-Term) (ABIN967162)

Target

Alle TDG Antikörper anzeigen
TDG (Thymine-DNA Glycosylase (TDG))

Reaktivität

  • 50
  • 18
  • 10
  • 2
  • 2
Human, Maus, Ratte

Wirt

  • 38
  • 12
Kaninchen

Klonalität

  • 41
  • 10
Polyklonal

Konjugat

  • 44
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TDG Antikörper ist unkonjugiert

Applikation

  • 41
  • 14
  • 11
  • 10
  • 6
  • 6
  • 5
  • 3
  • 3
  • 2
  • 1
Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Immunogen

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human TDG (G/T mismatch-specific thymine DNA glycosylase)
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Lagerung

    4 °C
  • Baba, Maita, Jee, Uchimura, Saitoh, Sugasawa, Hanaoka, Tochio, Hiroaki, Shirakawa: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).

    Hardeland, Steinacher, Jiricny, Schär: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).

    Neddermann, Gallinari, Lettieri, Schmid, Truong, Hsuan, Wiebauer, Jiricny: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).

    Neddermann, Jiricny: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).

  • Target

    TDG (Thymine-DNA Glycosylase (TDG))

    Andere Bezeichnung

    TDG

    Hintergrund

    In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. TDG(G/T mismatch-specific thymine DNA glycosylase) corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, TDG can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. TDG can also remove uracil and 5-bromouracil from mispairs with guanine. Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA. TDG belongs to the TDG/mug DNA glycosylase family.

    Pathways

    DNA Reparatur, Chromatin Binding
Sie sind hier:
Chat with us!