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TDG Antikörper (Internal Region)

TDG Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258811
  • Target Alle TDG Antikörper anzeigen
    TDG (Thymine-DNA Glycosylase (TDG))
    Bindungsspezifität
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 46
    • 19
    • 11
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 37
    • 10
    Kaninchen
    Klonalität
    • 40
    • 8
    Polyklonal
    Konjugat
    • 41
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TDG Antikörper ist unkonjugiert
    Applikation
    • 37
    • 10
    • 10
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    TDG Antibody detects endogenous levels of total TDG.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TDG, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product TDG Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    TDG (Thymine-DNA Glycosylase (TDG))
    Andere Bezeichnung
    TDG (TDG Produkte)
    Synonyme
    5-MCDG antikoerper, wu:fb44b11 antikoerper, zgc:110622 antikoerper, MGC82456 antikoerper, MGC89441 antikoerper, E130317C12Rik antikoerper, JZA-3 antikoerper, Jza1 antikoerper, hTDG antikoerper, thymine DNA glycosylase antikoerper, thymine DNA glycosylase, tandem duplicate 1 antikoerper, putative g/t mismatch-specific thymine DNA glycosylase antikoerper, G/T mismatch-specific thymine DNA glycosylase antikoerper, thymine DNA glycosylase S homeolog antikoerper, thymine-DNA glycosylase antikoerper, TDG antikoerper, tdg.1 antikoerper, Smp_149220 antikoerper, Tsp_05734 antikoerper, tdg.S antikoerper, tdg antikoerper, Tdg antikoerper
    Hintergrund

    Description: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

    Gene: TDG

    Molekulargewicht
    46 kDa
    Gen-ID
    6996
    UniProt
    Q13569
    Pathways
    DNA Reparatur, Chromatin Binding
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