GSK3 alpha Antikörper

Produktnummer ABIN966229

Dieser Monoklonal Antikörper detektiert spezifisch GSK3 alpha in WB, IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für GSK3 alpha Antikörper (ABIN966229)

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser GSK3 alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-GSK3 alpha Antikörper

Spezifität: Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Crude ascites.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Referenzen für anti-GSK3 alpha Antikörper (ABIN966229)

Sayas, Ariaens, Ponsioen, Moolenaar: "GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction." in: Molecular biology of the cell, Vol. 17, Issue 4, pp. 1834-44, (2006) (PubMed).

Bradley, Currie, MacMillan, Muir, McCarron: "Cyclic ADP-ribose increases Ca2+ removal in smooth muscle." in: Journal of cell science, Vol. 116, Issue Pt 21, pp. 4291-306, (2003) (PubMed).

Details zu GSK3 alpha

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Andere Bezeichnung: GSK3 alpha

Hintergrund: GSK3 alpha (Glycogen synthase kinase 3 alpha), with 483-amino acid protein (about 53kDa), belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily, which also includes GSK3 beta.GSK3 is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. GSK3 is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation.GSK3 alpha is implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.

Gen-ID: 11076

Pathways: PI3K-Akt Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effekt