FOXO1 Antikörper

Produktnummer ABIN966149

Produktdetails anti-FOXO1 Antikörper

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Spezifität: FKHR (Ab-319) antibody detects endogenous levels of total FKHR protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human FKHR around the phosphorylation site of serine 319.

Anwendungsinformationen

Applikationshinweise: WB: 1:500~1:1000
IHC: 1:50~1:100.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-FOXO1 Antikörper (ABIN966149)

Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: "Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 839-49, (2004) (PubMed).

Rena, Woods, Prescott, Peggie, Unterman, Williams, Cohen: "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion." in: The EMBO journal, Vol. 21, Issue 9, pp. 2263-71, (2002) (PubMed).

Rena, Prescott, Guo, Cohen, Unterman: "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting." in: The Biochemical journal, Vol. 354, Issue Pt 3, pp. 605-12, (2001) (PubMed).

Guo, Rena, Cichy, He, Cohen, Unterman: "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 17184-92, (1999) (PubMed).

Details zu FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Andere Bezeichnung: FKHR (FOXO1 Produkte)

Pathways: PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling