MECP2 Antikörper (N-Term)

Produktnummer ABIN953366

Produktdetails anti-MECP2 Antikörper

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human MeCP2 (N-term).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of Human MeCP2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2 (MECP2 Produkte)

Synonyme: AUTSX3 antikoerper, MRX16 antikoerper, MRX79 antikoerper, MRXS13 antikoerper, MRXSL antikoerper, PPMX antikoerper, RS antikoerper, RTS antikoerper, RTT antikoerper, 1500041B07Rik antikoerper, BB130002 antikoerper, D630021H01Rik antikoerper, Mbd5 antikoerper, WBP10 antikoerper, wu:fk96a04 antikoerper, zgc:111857 antikoerper, methyl-CpG binding protein 2 antikoerper, methyl CpG binding protein 2 antikoerper, methyl-CpG binding protein 2 S homeolog antikoerper, MECP2 antikoerper, Mecp2 antikoerper, mecp2 antikoerper, mecp2.S antikoerper

Hintergrund: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.Synonyms: MeCP-2 protein, Methyl-CpG-binding protein 2

Molekulargewicht: 52441 Da

Gen-ID: 4204

NCBI Accession: NP_001104262

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane