Cullin 2 Antikörper (Middle Region)

Produktnummer ABIN926903

Der Kaninchen Polyklonal Anti-Cullin 2-Antikörper wurde für WB validiert. Er ist geeignet, Cullin 2 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh) und Xenopus laevis zu detektieren.

Kurzübersicht für Cullin 2 Antikörper (Middle Region) (ABIN926903)

Target: Cullin 2 (CUL2)

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Cullin 2 Antikörper

Bindungsspezifität: Middle Region

Kreuzreaktivität: Maus, Ratte (Rattus), Hund, Rind (Kuh), Frosch

Aufreinigung: Purified

Immunogen: CUL2 antibody was raised in rabbit using the middle region of CUL2 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

CUL2 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CUL2 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu Cullin 2

Target: Cullin 2 (CUL2)

Andere Bezeichnung: CUL2

Hintergrund: CUL2 is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This protein may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Synonyms: Polyclonal CUL2 antibody, Anti-CUL2 antibody, cullin 2 antibody, MGC131970 antibody.

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interaktom