CDK8 Antikörper (C-Term)

Produktnummer ABIN926004

Dieses Anti-CDK8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CDK8 in WB. Geeignet für Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Huhn und Xenopus laevis.

Kurzübersicht für CDK8 Antikörper (C-Term) (ABIN926004)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDK8 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Maus, Ratte (Rattus), Hund, Zebrafisch (Brachydanio rerio), Frosch, Huhn

Immunogen: CDK8 antibody was raised in rabbit using the C terminal of CDK8 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

CDK8 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CDK8 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: CDK8

Hintergrund: The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. Synonyms: Polyclonal CDK8 antibody, Anti-CDK8 antibody, cyclin-dependent kinase 8 antibody.

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha