CDK8 Antikörper (N-Term)

Produktnummer ABIN391759

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CDK8 in WB. Es zeigt Reaktivität gegenüber Proben von Human.Es wurde in 1 Publikation zitiert.

Kurzübersicht für CDK8 Antikörper (N-Term) (ABIN391759)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB3200

Produktdetails anti-CDK8 Antikörper

Bindungsspezifität: AA 1-30, N-Term

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDK8.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CDK8 Antikörper (ABIN391759)

Han, Zheng, Ge, Wang, Xiang, Wang: "Downregulation of cyclin-dependent kinase 8 by microRNA-148a suppresses proliferation and invasiveness of papillary thyroid carcinomas." in: American journal of cancer research, Vol. 7, Issue 10, pp. 2081-2090, (2018) (PubMed).

Details zu CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: CDK8

Hintergrund: CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Molekulargewicht: 53284

Gen-ID: 1024

NCBI Accession: NP_001251

UniProt: P49336

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha