TLR9 Antikörper (Internal Region)

Produktnummer ABIN920629

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TLR9 in WB und ICC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TLR9 Antikörper (Internal Region) (ABIN920629)

Target: TLR9 (Toll-Like Receptor 9 (TLR9))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC)

Produktdetails anti-TLR9 Antikörper

Bindungsspezifität: Internal Region

Produktmerkmale: Positive Control: Jurkat cell lysate. Located in the membrane, and highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Aufreinigung: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR9 antibody was raised against a peptide corresponding to 15 amino acids near the center of human TLR9.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: use at 0.5-1 µg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TLR9

Target: TLR9 (Toll-Like Receptor 9 (TLR9))

Hintergrund: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TRL9 is strictly dependent on MyD88. Synonyms:

Molekulargewicht: 116 kDa

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades