PKM2 Antikörper (AA 301-350)

Produktnummer ABIN8124183

Der Kaninchen Polyklonal anti-PKM2 Antikörper wird verwendet zum Nachweis von PKM2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für PKM2 Antikörper (AA 301-350) (ABIN8124183)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PKM2 Antikörper

Bindungsspezifität: AA 301-350

Verwendungszweck: PKM2 Antibody

Spezifität: This antibody detects endogenous levels of human PKM2

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human PKM2 AA range: 301-350

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-200, WB 1:500-2000. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung: PKM2

Hintergrund:

Synonyms: Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58)

Background: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011],

Gene Name: PKM OIP3 PK2 PK3 PKM2

Protein Name: PKM2

Gen-ID: 5315

UniProt: P14618

Pathways: Warburg Effekt