XPC Antikörper (AA 146-838) (HRP)

Produktnummer ABIN8054817

Der Kaninchen Polyklonal anti-XPC Antikörper wird verwendet zum Nachweis von XPC in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für XPC Antikörper (AA 146-838) (HRP) (ABIN8054817)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPC Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-XPC Antikörper (HRP)

Bindungsspezifität: AA 146-838

Verwendungszweck: Anti-XPC Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human XPC recombinant protein (Position: D146-E838).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Andere Bezeichnung: XPC

Hintergrund:

Background: Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: XPC complex subunit, DNA damage recognition and repair factor

Gen-ID: 7508

UniProt: Q01831

Pathways: p53 Signalweg, DNA Reparatur