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XPC Antikörper (C-Term)

XPC Reaktivität: Human WB, ICC, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855495
  • Target Alle XPC Antikörper anzeigen
    XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))
    Bindungsspezifität
    • 14
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 45
    • 3
    • 3
    • 1
    Human
    Wirt
    • 44
    • 5
    Kaninchen
    Klonalität
    • 45
    • 4
    Polyklonal
    Konjugat
    • 26
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser XPC Antikörper ist unkonjugiert
    Applikation
    • 34
    • 25
    • 10
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus)
    Kreuzreaktivität (Details)
    Rat (85 %)
    Produktmerkmale
    Rabbit Polyclonal antibody to XPC (xeroderma pigmentosum, complementation group C)
    XPC antibody [C2C3], C-term
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human XPC. The exact sequence is proprietary.
    Isotyp
    IgG
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    Discover our top product XPC Primärantikörper
  • Applikationshinweise
    Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Kommentare

    Positive Control: NT2D1 , IMR32 , U87-MG , MCF-7

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.67 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Lemoine, Bayrambey, Roloff, Hutzler, Luch, Tralau: "Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[a]Pyrene Metabolite Profile and Its Distribution in 3D Skin." in: mBio, Vol. 12, Issue 5, pp. e0122321, (2022) (PubMed).

  • Target
    XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))
    Andere Bezeichnung
    XPC (XPC Produkte)
    Synonyme
    RAD4 antikoerper, XP3 antikoerper, XPCC antikoerper, XPC complex subunit, DNA damage recognition and repair factor antikoerper, xeroderma pigmentosum, complementation group C antikoerper, XPC antikoerper, Xpc antikoerper
    Hintergrund
    This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

    Cellular Localization: Nucleus
    Molekulargewicht
    106 kDa
    Gen-ID
    7508
    Pathways
    p53 Signalweg, DNA Reparatur
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