XPC Antikörper (N-Term)

Produktnummer ABIN1882000

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch XPC in WB. Es zeigt Reaktivität gegenüber Proben von Human.Es wurde in 1 Publikation zitiert.

Kurzübersicht für XPC Antikörper (N-Term) (ABIN1882000)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40964

Produktdetails anti-XPC Antikörper

Bindungsspezifität: AA 154-183, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-XPC Antikörper (ABIN1882000)

Stern, Lin, Figueroa, Kelsey, Kiltie, Yuan, Matullo, Fletcher, Benhamou, Taylor, Placidi, Zhang, Steineck, Rothman, Kogevinas, Silverman, Malats, Chanock, Wu, Karagas: "Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer." in: Cancer research, Vol. 69, Issue 17, pp. 6857-64, (2009) (PubMed).

Details zu XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Andere Bezeichnung: XPC

Hintergrund: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Molekulargewicht: 105953

NCBI Accession: NP_001139241, NP_004619

UniProt: Q01831

Pathways: p53 Signalweg, DNA Reparatur