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IRAK4 Antikörper (pThr345)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IRAK4 in WB, IF (p) und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Schwein und Hund.
Produktnummer ABIN753538

Kurzübersicht für IRAK4 Antikörper (pThr345) (ABIN753538)

Target

Alle IRAK4 Antikörper anzeigen
IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reaktivität

  • 110
  • 60
  • 22
  • 14
  • 13
  • 11
  • 4
  • 3
  • 2
  • 2
  • 1
Human, Maus, Ratte, Rind (Kuh), Schwein, Hund

Wirt

  • 103
  • 15
  • 1
Kaninchen

Klonalität

  • 100
  • 19
Polyklonal

Konjugat

  • 59
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IRAK4 Antikörper ist unkonjugiert

Applikation

  • 110
  • 48
  • 36
  • 26
  • 20
  • 17
  • 15
  • 10
  • 9
  • 8
  • 5
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 28
    • 16
    • 11
    • 8
    • 8
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr345

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human IRAK4 around the phosphorylation site of Thr345

    Isotyp

    IgG
  • Applikationshinweise

    WB(1:100-500)
    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

    Andere Bezeichnung

    IRAK4

    Hintergrund

    Synonyms: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, IRAK4

    Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

    Molekulargewicht

    51kDa

    Gen-ID

    51135

    UniProt

    Q9NWZ3

    Pathways

    NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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