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IRAK4 Antikörper

IRAK4 Reaktivität: Human, Maus, Affe WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 2H9 unconjugated
Produktnummer ABIN969218
  • Target Alle IRAK4 Antikörper anzeigen
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Reaktivität
    • 116
    • 66
    • 27
    • 16
    • 14
    • 13
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Affe
    Wirt
    • 109
    • 12
    • 1
    Maus
    Klonalität
    • 108
    • 14
    Monoklonal
    Konjugat
    • 52
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser IRAK4 Antikörper ist unkonjugiert
    Applikation
    • 111
    • 51
    • 37
    • 26
    • 17
    • 16
    • 14
    • 10
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human IRAK4 expressed in E. coli.
    Klon
    2H9
    Isotyp
    IgG1
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Dunne, Carpenter, Brikos, Gray, Strelow, Wesche, Morrice, ONeill: "IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18276-82, (2010) (PubMed).

    Pathak, De Souza, Salte, Wiker, Asjö: "HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells." in: Scandinavian journal of immunology, Vol. 70, Issue 3, pp. 264-76, (2009) (PubMed).

  • Target
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Andere Bezeichnung
    IRAK4 (IRAK4 Produkte)
    Synonyme
    zgc:55553 antikoerper, IRAK4 antikoerper, ipd1 antikoerper, irak-4 antikoerper, ny-ran-64 antikoerper, ny-ren-64 antikoerper, ren64 antikoerper, irak4 antikoerper, IPD1 antikoerper, IRAK-4 antikoerper, NY-REN-64 antikoerper, REN64 antikoerper, 8430405M07Rik antikoerper, 9330209D03Rik antikoerper, interleukin 1 receptor associated kinase 4 antikoerper, interleukin-1 receptor-associated kinase 4 antikoerper, IRAK4 antikoerper, irak4 antikoerper, Irak4 antikoerper
    Hintergrund

    Description: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

    Aliases: IPD1, REN64, NY-REN-64

    Molekulargewicht
    52 kDa
    Gen-ID
    51135
    HGNC
    51135
    Pathways
    NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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