AIM2 Antikörper (AA 136-354) (HRP)

Produktnummer ABIN7965402

Der HRP-konjugierte Kaninchen Polyklonal anti-AIM2 Antikörper (ABIN7965402) detektiert spezifisch AIM2 in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für AIM2 Antikörper (AA 136-354) (HRP) (ABIN7965402)

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIM2 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-AIM2 Antikörper (HRP)

Bindungsspezifität: AA 136-354

Verwendungszweck: Anti-Aim2 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Aim2 recombinant protein (Position: Q136-E354).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Andere Bezeichnung: Aim2

Hintergrund:

Background: Interferon-inducible protein AIM2,also known asabsent in melanoma 2or simplyAIM2,is aproteinthat in humans is encoded by theAIM2gene. It is mapped to 1q22. AIM2 is a member of theIfi202/IFI16family. It plays a putative role in tumorigenic reversion and may control cell proliferation.Interferon-gammainduces expression of AIM2. Though there has been virtually no biochemistry performed, a model based on cell-based or in vivo experiments has led to the current model of how AIM2 triggers the inflammasome. The C-terminal HIN domain binds double stranded DNA(either viral, bacterial, or even host) and acts as a cytosolic dsDNA sensor. This leads to the oligomerization of the inflammasome complex. The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another proteinASC(or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain). ASC also contains aCARD domain(caspase activation and recruitment domain), that recruits procaspase-1 to the complex. This leads to the autoactivation ofcaspase-1, an enzyme that processes proinflammatorycytokines(IL-1bandIL-18).

Gene Full Name: absent in melanoma 2

Gen-ID: 383619

UniProt: Q91VJ1

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome