Growth Hormone Receptor Antikörper

Produktnummer ABIN7880933

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Growth Hormone Receptor in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Growth Hormone Receptor Antikörper (ABIN7880933)

Target: Growth Hormone Receptor (GHR)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Growth Hormone Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 17G57

Produktdetails anti-Growth Hormone Receptor Antikörper

Verwendungszweck: GHR Antibody / Growth Hormone Receptor

Aufreinigung: Affinity purified

Immunogen: A synthetic peptide specific to human Growth Hormone Receptor / GHR was used as the immunogen for the GHR antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GHR antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the GHR antibody at -20oC.

Details zu Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Andere Bezeichnung: GHR

Hintergrund: The GHR gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. [RefSeq]

UniProt: P10912

Pathways: NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus