IGF1 Antikörper (AA 45-161)

Produktnummer ABIN7875056

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IGF1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für IGF1 Antikörper (AA 45-161) (ABIN7875056)

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IGF1 Antikörper

Bindungsspezifität: AA 45-161

Verwendungszweck: Zebrafish Insulin like growth factor 1 Antibody / Igf1

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Insulin like growth factor 1 recombinant protein (amino acids G45-M161) was used as the immunogen for the Zebrafish Insulin like growth factor 1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Insulin like growth factor 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Insulin like growth factor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IGF1

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Andere Bezeichnung: Insulin like growth factor 1

Hintergrund: Insulin like growth factor 1, also known as IGF1, is a peptide growth factor that plays a key role in regulating cell growth, differentiation, and survival. In zebrafish, insulin like growth factor 1 is essential for normal embryonic development, tissue regeneration, and metabolic regulation.

IGF1 is produced mainly in the liver and acts both locally and systemically through endocrine and paracrine signaling. It mediates many of the growth promoting effects of growth hormone and functions by binding to its specific receptor on the cell surface, triggering downstream signaling pathways that influence cell cycle progression, protein synthesis, and apoptosis inhibition.

In zebrafish, insulin like growth factor 1 is involved in the development of multiple organs including the brain, heart, and skeletal muscle. It also supports fin regeneration and contributes to recovery from injury by promoting cell proliferation and tissue remodeling. IGF1 expression is sensitive to nutritional status and environmental factors, making it a key biomarker for growth and metabolic studies.

Due to its strong conservation across vertebrates and its broad physiological importance, zebrafish insulin like growth factor 1 is widely used in research related to developmental biology, growth regulation, endocrine function, metabolic disease, and regenerative medicine.

UniProt: Q90VV9

Pathways: RTK Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation