GATA4 Antikörper (AA 262-321)

Produktnummer ABIN7873034

Dieser Maus Monoklonal Antikörper detektiert spezifisch GATA4 in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GATA4 Antikörper (AA 262-321) (ABIN7873034)

Target: GATA4 (GATA Binding Protein 4 (GATA4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GATA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PCRP-GATA4-1A7

Produktdetails anti-GATA4 Antikörper

Bindungsspezifität: AA 262-321

Verwendungszweck: GATA4 Antibody / GATA-binding factor 4

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 262-321) from the human protein was used as the immunogen for the GATA4 antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GATA4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot the GATA4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GATA4

Target: GATA4 (GATA Binding Protein 4 (GATA4))

Andere Bezeichnung: GATA4

Hintergrund: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4, expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

UniProt: P43694

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis