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GATA4 Antikörper (pSer105)

GATA4 Reaktivität: Human, Ratte, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256094
  • Target Alle GATA4 Antikörper anzeigen
    GATA4 (GATA Binding Protein 4 (GATA4))
    Bindungsspezifität
    • 15
    • 12
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer105
    Reaktivität
    • 86
    • 64
    • 63
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 79
    • 8
    Kaninchen
    Klonalität
    • 70
    • 17
    Polyklonal
    Konjugat
    • 52
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GATA4 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 28
    • 19
    • 17
    • 13
    • 13
    • 11
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-GATA4 (Ser105) Antibody detects endogenous levels of GATA4 only when phosphorylated at Serine 105.
    Homologie
    Pig,Bovine,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human GATA4 around the phosphorylation site of Ser105.
    Isotyp
    IgG
    Top Product
    Discover our top product GATA4 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    GATA4 (GATA Binding Protein 4 (GATA4))
    Andere Bezeichnung
    GATA4 (GATA4 Produkte)
    Synonyme
    gata-4 antikoerper, xgata4 antikoerper, xGATA-4 antikoerper, MGC81427 antikoerper, GATA4 antikoerper, GATA-4 antikoerper, Gata4 antikoerper, gata4 antikoerper, ASD2 antikoerper, VSD1 antikoerper, Gata-4 antikoerper, gata antikoerper, GATA binding protein 4 antikoerper, GATA binding protein 4 L homeolog antikoerper, glutamyl-tRNA(Gln) amidotransferase subunit A antikoerper, gata4 transcription factor antikoerper, GATA binding protein 4 S homeolog antikoerper, GATA4 antikoerper, gata4.L antikoerper, gata4 antikoerper, gatA4 antikoerper, Gata4 antikoerper, gata4.S antikoerper
    Hintergrund

    Description: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).

    Gene: GATA4

    Molekulargewicht
    44kDa
    Gen-ID
    2626
    UniProt
    P43694
    Pathways
    Peptide Hormone Metabolism, Carbohydrate Homeostasis
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