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GATA4 Antikörper (pSer262)

GATA4 Reaktivität: Human, Ratte, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256227
  • Target Alle GATA4 Antikörper anzeigen
    GATA4 (GATA Binding Protein 4 (GATA4))
    Bindungsspezifität
    • 15
    • 12
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer262
    Reaktivität
    • 86
    • 64
    • 63
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 79
    • 8
    Kaninchen
    Klonalität
    • 70
    • 17
    Polyklonal
    Konjugat
    • 52
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GATA4 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 28
    • 19
    • 17
    • 13
    • 13
    • 11
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-GATA4 (Ser262) Antibody detects endogenous levels of GATA4 only when phosphorylated at Serine 262.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human GATA4 around the phosphorylation site of Ser262.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    GATA4 (GATA Binding Protein 4 (GATA4))
    Andere Bezeichnung
    GATA4 (GATA4 Produkte)
    Synonyme
    gata-4 antikoerper, xgata4 antikoerper, xGATA-4 antikoerper, MGC81427 antikoerper, GATA4 antikoerper, GATA-4 antikoerper, Gata4 antikoerper, gata4 antikoerper, ASD2 antikoerper, VSD1 antikoerper, Gata-4 antikoerper, gata antikoerper, GATA binding protein 4 antikoerper, GATA binding protein 4 L homeolog antikoerper, glutamyl-tRNA(Gln) amidotransferase subunit A antikoerper, gata4 transcription factor antikoerper, GATA binding protein 4 S homeolog antikoerper, GATA4 antikoerper, gata4.L antikoerper, gata4 antikoerper, gatA4 antikoerper, Gata4 antikoerper, gata4.S antikoerper
    Hintergrund

    Description: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).

    Gene: GATA4

    Molekulargewicht
    48kDa
    Gen-ID
    2626
    UniProt
    P43694
    Pathways
    Peptide Hormone Metabolism, Carbohydrate Homeostasis
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