MCM6 Antikörper (AA 228-368)

Produktnummer ABIN7872423

Der Maus Monoklonal anti-MCM6 Antikörper wird verwendet zum Nachweis von MCM6 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für MCM6 Antikörper (AA 228-368) (ABIN7872423)

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MCM6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MCM6-2999

Produktdetails anti-MCM6 Antikörper

Bindungsspezifität: AA 228-368

Verwendungszweck: MCM6 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 228-368) was used as the immunogen for this MCM6 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MCM6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the MCM6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu MCM6

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Andere Bezeichnung: MCM6

Hintergrund: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.

UniProt: Q14566

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA