PYCARD Antikörper (AA 1-195)

Produktnummer ABIN7868349

Der Kaninchen Polyklonal anti-PYCARD Antikörper wird verwendet zum Nachweis von PYCARD in Proben von Human. Er wurde validiert für WB, ELISA, IF, FACS und IHC (p).

Kurzübersicht für PYCARD Antikörper (AA 1-195) (ABIN7868349)

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYCARD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PYCARD Antikörper

Bindungsspezifität: AA 1-195

Verwendungszweck: TMS1 Antibody / Target of methylation-induced silencing 1 / PYCARD

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-S195) was used as the immunogen for the TMS1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TMS1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TMS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PYCARD

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Andere Bezeichnung: TMS1

Hintergrund: PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD) and Target of methylation-induced silencing 1 (TMS1), is a protein that in humans is encoded by the PYCARD gene. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q9ULZ3

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome