PYCARD Antikörper (AA 50-195)

Produktnummer ABIN3021617

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-PYCARD Antikörper wird verwendet zum Nachweis von PYCARD in Proben von Human. Er wurde validiert für WB und IF.

Kurzübersicht für PYCARD Antikörper (AA 50-195) (ABIN3021617)

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYCARD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-PYCARD Antikörper

Bindungsspezifität: AA 50-195

Sequenz: LDLTDKLVSF YLETYGAELT ANVLRDMGLQ EMAGQLQAAT HQGSGAAPAG IQAPPQSAAK PGLHFIDQHR AALIARVTNV EWLLDALYGK VLTDEQYQAV RAEPTNPSKM RKLFSFTPAW NWTCKDLLLQ ALRESQSYLV EDLERS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-195 of human ASC / TMS1 (NP_037390.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-PYCARD Antikörper (ABIN3021617)

Deng, Zou, Xiong, Wang, Engelhardt, Ye, Yan, Qiu: "Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis." in: Journal of virology, Vol. 91, Issue 24, (2017) (PubMed).

Details zu PYCARD

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Andere Bezeichnung: PYCARD

Hintergrund: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.,PYCARD,ASC,CARD5,TMS,TMS-1,TMS1,PYD and CARD domain containing,ASC / TMS1,Cancer,Tumor biomarkers,Cell Biology & Developmental Biology,Apoptosis,Caspases,PYCARD

Molekulargewicht: 15 kDa/19 kDa/21 kDa

Gen-ID: 29108

UniProt: Q9ULZ3

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome