Rekombinanter Complement Factor B Antikörper (PE)

Produktnummer ABIN7867224

Der Kaninchen Chimeric anti-Complement Factor B Antikörper wird verwendet zum Nachweis von Complement Factor B in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für Rekombinanter Complement Factor B Antikörper (PE) (ABIN7867224)

Target: Complement Factor B (CFB)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser Complement Factor B Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: DMC366

Produktdetails anti-Complement Factor B Antikörper (PE)

Verwendungszweck: PE-conjugated Anti-CFB antibody(DMC366), IgG1 Chimeric mAb

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cyt 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C-8°C for 6 months

Haltbarkeit: 6 months

Details zu Complement Factor B

Target: Complement Factor B (CFB)

Andere Bezeichnung: CFB

Hintergrund:

Synonyms: AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2

Target Background: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

UniProt: P00751

Pathways: Komplementsystem, Proton Transport, Ribonucleoside Biosynthetic Process