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Complement Factor B Antikörper

CFB Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855659
  • Target Alle Complement Factor B (CFB) Antikörper anzeigen
    Complement Factor B (CFB)
    Reaktivität
    • 70
    • 44
    • 35
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 90
    • 15
    • 2
    Kaninchen
    Klonalität
    • 91
    • 15
    • 1
    Polyklonal
    Konjugat
    • 45
    • 19
    • 15
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Complement Factor B Antikörper ist unkonjugiert
    Applikation
    • 80
    • 39
    • 30
    • 16
    • 13
    • 13
    • 11
    • 10
    • 9
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Rabbit Polyclonal antibody to Factor B (complement factor B)
    Factor B antibody [N2C2], Internal
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human Factor B. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product CFB Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Validation: Orthogonal

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.87 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Zhu, Yao, Duan, Xu, Cheng, Gao, Li, Yang, Liu, Yuan: "Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3." in: International journal of molecular sciences, Vol. 21, Issue 4, (2020) (PubMed).

  • Target
    Complement Factor B (CFB)
    Andere Bezeichnung
    complement factor B (CFB Produkte)
    Synonyme
    AHUS4 antikoerper, BF antikoerper, BFD antikoerper, CFAB antikoerper, FB antikoerper, FBI12 antikoerper, GBG antikoerper, H2-Bf antikoerper, PBF2 antikoerper, bf antikoerper, Bf-1 antikoerper, Brre-Bf antikoerper, zgc:114032 antikoerper, Bf antikoerper, Sp152 antikoerper, bfb-A antikoerper, Bf B antikoerper, LOC397725 antikoerper, bf/c2 antikoerper, CFB antikoerper, AI195813 antikoerper, AI255840 antikoerper, B antikoerper, C2 antikoerper, Fb antikoerper, Da1-24 antikoerper, complement factor B antikoerper, complement factor B S homeolog antikoerper, complement factor B L homeolog antikoerper, CFB antikoerper, cfb antikoerper, bf antikoerper, cfb.S antikoerper, cfb.L antikoerper, bf/c2 antikoerper, LOC100555981 antikoerper, Cfb antikoerper
    Hintergrund
    This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

    Cellular Localization: Secreted
    Molekulargewicht
    86 kDa
    Gen-ID
    629
    UniProt
    P00751
    Pathways
    Komplementsystem, Proton Transport, Ribonucleoside Biosynthetic Process
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