GATA4 Antikörper (AA 262-321)

Produktnummer ABIN7859676

Der Maus Monoklonal anti-GATA4 Antikörper wird verwendet zum Nachweis von GATA4 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für GATA4 Antikörper (AA 262-321) (ABIN7859676)

Target: GATA4 (GATA Binding Protein 4 (GATA4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GATA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PCRP-GATA4-1A7

Produktdetails anti-GATA4 Antikörper

Bindungsspezifität: AA 262-321

Verwendungszweck: GATA4 Antibody

Spezifität: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4, expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa262-321) of human GATA4 protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu GATA4

Target: GATA4 (GATA Binding Protein 4 (GATA4))

Andere Bezeichnung: GATA4

Hintergrund:

ASD2, GATA 4, GATA binding protein 4, GATA-binding factor 4, gata4, GATA4_HUMAN, MGC126629, Transcription factor GATA 4, Transcription factor GATA-4, Transcription factor GATA4, VSD1

HeLa or MCF-7 cells.

Molekulargewicht: 44.57kDa

Gen-ID: 2626, 243987

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis