Rekombinanter DIABLO Antikörper

Produktnummer ABIN7828549

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch DIABLO in WB, IHC, IF, IP und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter DIABLO Antikörper (ABIN7828549)

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser DIABLO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Klon: A361

Produktdetails anti-DIABLO Antikörper

Verwendungszweck: Recombinant Smac/Diablo Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human Smac/Diablo fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000,IHC 1:50-1:100,IF 1:500-1:1000,FCM 1:50-1:100,IP 1:25-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Andere Bezeichnung: Smac/Diablo

Hintergrund: DFNA,DIABLO,DFNA64,SMAC,0610041G12Rik,DBLOH,DBOH,Diablo homolog,Diablo homolog (Drosophila),Diablo homolog mitochondrial,Diablo IAP binding mitochondrial protein,Diablo like protein,DIABLO S,Direct IAP binding protein with low pI,Direct IAP-binding protein with low pI,FLJ10537,FLJ25049,mitochondrial,Mitochondrial Smac protein,Second mitochondria derived activator of caspase,Second mitochondria-derived activator of caspase,SMAC 3,Smac protein,SMAC3,Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 27 kDa

Observed MW: 21 kDa The actual band is not consistent with the expectation.

UniProt: Q9NR28

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity