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DIABLO Antikörper (AA 131-239)

DIABLO Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (cc) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN674619
  • Target Alle DIABLO Antikörper anzeigen
    DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
    Bindungsspezifität
    • 10
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 131-239
    Reaktivität
    • 61
    • 27
    • 26
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 54
    • 7
    • 1
    Kaninchen
    Klonalität
    • 44
    • 18
    Polyklonal
    Konjugat
    • 37
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Dieser DIABLO Antikörper ist unkonjugiert
    Applikation
    • 35
    • 16
    • 14
    • 11
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Smac
    Isotyp
    IgG
    Top Product
    Discover our top product DIABLO Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Liu, Chen, Li, Wang, Cheng: "Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts." in: International journal of molecular medicine, Vol. 32, Issue 3, pp. 615-22, (2013) (PubMed).

  • Target
    DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
    Andere Bezeichnung
    Smac/DIABLO (DIABLO Produkte)
    Synonyme
    smac antikoerper, smac3 antikoerper, diablo-s antikoerper, 0610041G12Rik antikoerper, 1700006L01Rik antikoerper, AU040403 antikoerper, Smac antikoerper, DFNA64 antikoerper, SMAC antikoerper, DBO antikoerper, XSmac antikoerper, diablo, IAP-binding mitochondrial protein antikoerper, diablo IAP-binding mitochondrial protein antikoerper, diablo, IAP-binding mitochondrial protein L homeolog antikoerper, diablo antikoerper, Diablo antikoerper, DIABLO antikoerper, diablo.L antikoerper
    Hintergrund

    Synonyms: SMAC, DFNA64, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, DIABLO

    Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

    Gen-ID
    56616
    UniProt
    Q9NR28
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
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