Rekombinanter p21 Antikörper (AA 100-150)

Produktnummer ABIN7795764

Der Kaninchen Monoklonal Anti-p21 Antikörper wurde für WB, IHC, IP und ICC validiert. Er ist geeignet, p21 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter p21 Antikörper (AA 100-150) (ABIN7795764)

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser p21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: BLR337M

Produktdetails anti-p21 Antikörper

Bindungsspezifität: AA 100-150

Verwendungszweck: Rabbit anti-p21/CIP1/CDKN1A Recombinant Monoclonal Antibody [BLR337M]

Aufreinigung: Purified

Immunogen: between 100 and 150

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ICC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.,IHC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.,WB,11,000,IP,12 μL/mg lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 500 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2 - 8 °C

Haltbarkeit: 12 months

Details zu p21

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Andere Bezeichnung: p21/CIP1/CDKN1A

Hintergrund: P21/CIP1/CDKN1A is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. Expression of p21/CIP1/CDKN1A is tightly controlled by the tumor suppressor protein p53, and it mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. p21/CIP1/CDKN1A can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. [taken from NCBI Entrez Gene (Gene ID: 1026)].

Gen-ID: 1026

UniProt: P38936

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Zellzyklus, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagie