TNF alpha Antikörper (PE,Cy7)

Produktnummer ABIN7670269

Der Ratte Monoklonal Anti-TNF alpha-Antikörper wurde für ICFC validiert. Er ist geeignet, TNF alpha in Proben von Maus zu detektieren.

Kurzübersicht für TNF alpha Antikörper (PE,Cy7) (ABIN7670269)

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser TNF alpha Antikörper ist konjugiert mit PE,Cy7

Applikation: Intracellular Flow Cytometry (ICFC)

Klon: XT3-11

Produktdetails anti-TNF alpha Antikörper (PE,Cy7)

Verwendungszweck: PE/Cyanine7 Anti-Mouse TNFα Antibody[XT3.11]

Immunogen: E-AB-F09822H

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 5 μL/tests

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant

Handhabung: Please protected from prolonged exposure to light and do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: This product can be stored at 2-8°C for 12 months.

Haltbarkeit: 12 months

Details zu TNF alpha

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Andere Bezeichnung: TNF-alpha

Hintergrund: Tumor necrosis factor-α,Cachectin,Necrosin,Macrophage cytotoxic factor,Differentiation inducing factor,TNFSF-2,TNF-a,TNF-alpha,TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric mouse TNF-α is a 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kD. TNF-α forms multimeric complexes, stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorrhagic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

UniProt: P06804

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome