FADD Antikörper

Produktnummer ABIN7604814

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch FADD in WB, IHC und FACS. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für FADD Antikörper (ABIN7604814)

Target: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FADD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: ADDE-6

Produktdetails anti-FADD Antikörper

Verwendungszweck: Anti-FADD Monoclonal Antibody

Produktmerkmale: Anti-FADD Monoclonal Antibody (ABIN7604814). Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Mouse.

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human FADD Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000
IHC 1:50-200
FC 1:20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Konzentration: 0.5 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Details zu FADD

Target: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Andere Bezeichnung: Fadd

Hintergrund:

Synonyms: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha,PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6,PPARGC1A,LEM6, PGC1, PGC1A, PPARGC1,

Tissue Specificity: Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. .

Molekulargewicht: 100-110 kDa

UniProt: Q61160

Pathways: Apoptose, TLR Signalweg, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades