Growth Hormone Receptor Antikörper (AA 25-650)

Produktnummer ABIN7600919

Dieses Anti-Growth Hormone Receptor-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Growth Hormone Receptor in WB, ELISA und FACS. Geeignet für Maus und Ratte.

Kurzübersicht für Growth Hormone Receptor Antikörper (AA 25-650) (ABIN7600919)

Target: Growth Hormone Receptor (GHR)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Growth Hormone Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Growth Hormone Receptor Antikörper

Bindungsspezifität: AA 25-650

Verwendungszweck: Anti-Growth hormone receptor/GHR Picoband® Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Growth hormone receptor/GHR Picoband® Antibody (ABIN7600919). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Growth hormone receptor/GHR recombinant protein (Position: T25-Q650).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Horan, M., Newsway, V., Yasmin, (NI), Lewis, M. D., Easter, T. E., Rees, D. A., Mahto, A., Millar, D. S., Procter, A. M., Scanlon, M. F., Wilkinson, I. B., Hall, I. P., Wheatley, A., Blakey, J., Bath, P. M. W., Cockcroft, J. R., Krawczak, M., Cooper, D. N. Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke. Hum. Genet. 119: 527-540, 2006. 2. Pantel, J., Grulich-Henn, J., Bettendorf, M., Strasburger, C. J., Heinrich, U., Amselem, S. Heterozygous nonsense mutation in exon 3 of the growth hormone receptor (GHR) in severe GH insensitivity (Laron syndrome) and the issue of the origin and function of the GHRd3 isoform. J. Clin. Endocr. Metab. 88: 1705-1710, 2003. 3. Tiulpakov, A., Rubstov, P., Dedov, I., Peterkova, V., Bezlepkina, O., Chrousos, G. P., Hochberg, Z. A novel C-terminal growth hormone receptor (GHR) mutation results in impaired GHR-STAT5 but normal STAT-3 signaling. J. Clin. Endocr. Metab. 90: 542-547, 2005.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Andere Bezeichnung: Ghr

Hintergrund:

Synonyms: Growth hormone receptor, GH receptor, Somatotropin receptor, Growth hormone-binding protein, GH-binding protein, GHBP, Serum-binding protein, Ghr

Tissue Specificity: Expressed in lung and placenta.

Background: Growth hormone receptor is a protein that in humans is encoded by the GHR gene. It is mapped to 15 A1, 15 1.84 cM. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

Molekulargewicht: 130 kDa

Gen-ID: 14600

UniProt: P16882

Pathways: NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus