BRAF Antikörper

Produktnummer ABIN7598850

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch BRAF in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für BRAF Antikörper (ABIN7598850)

Target: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser BRAF Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: G11-G

Produktdetails anti-BRAF Antikörper

Verwendungszweck: Anti-Braf

Spezifität: Braf

Immunogen: Peptide derived from human B-raf surrounding the Val-600 residue (corresponds to Val 637 of mouse or rat B-raf)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 20 mM Tris-HCI, pH 8.0, Stabilizer: 20 mg/mL BSA, Preservative: 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: +2 °C to +8 °C

Details zu BRAF

Target: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Andere Bezeichnung: Braf

Hintergrund: B-raf proto-oncogene belongs to a large group of serine/threonine kinases of RAF family, involved in the transduction of mitogenic signals from the cell membrane to the nucleus. This protein kinase is frequently mutated in thyroid cancer and human melanomas, less frequently in other types of malignant tissues, including colorectal cancers, lung cancers and gliomas. Ninety percent of B-raf mutations are represented by B-raf V600-E mutation, presented by up to 500-fold increased activation in MEK/ERK signaling in tumor cells.

UniProt: P15056

Pathways: MAPK Signalweg, RTK Signalweg, Neurotrophin Signalübertragung, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagie