NPM1 Antikörper (AA 1-294)

Produktnummer ABIN7596068

Dieses Anti-NPM1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von NPM1 in WB, ELISA, IF, FACS und ICC. Geeignet für Human.

Kurzübersicht für NPM1 Antikörper (AA 1-294) (ABIN7596068)

Target: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NPM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: AT23F1

Produktdetails anti-NPM1 Antikörper

Bindungsspezifität: AA 1-294

Verwendungszweck: Human NPM1 antibody

Aufreinigung: protein-A affinity chromatography

Immunogen: Recombinant human NPM1(1-294aa) purified from E. coli

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Details zu NPM1

Target: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Andere Bezeichnung: NPM1

Hintergrund: NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded and double-strandednucleic acids, but it binds preferentially G-Quadruplex forming nucleic acids. It is involved in the biogenesisof ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation throughSUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions.It is located in the nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation ortreatment with anticancer drugs. The protein is phosphorylated. Chromosomal aberrations involving NPM1 werefound in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acutemyelogenous leukemia. It has been found in the cytoplasm in patients with primary acute myelogenous leukemia.

NCBI Accession: NP_002511

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly