VAV1 Antikörper

Produktnummer ABIN7469172

Dieser Maus Monoklonal Antikörper detektiert spezifisch VAV1 in WB, IHC (p), IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für VAV1 Antikörper (ABIN7469172)

Target: VAV1 (Vav 1 Oncogene (VAV1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser VAV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: GT557

Produktdetails anti-VAV1 Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: Affinity purified by Protein G.

Immunogen: Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Jurkat , NCI-H929

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Andere Bezeichnung: vav guanine nucleotide exchange factor 1

Hintergrund:

Synonyms: vav guanine nucleotide exchange factor 1 , VAV

Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]

Molekulargewicht: 98 kDa

Gen-ID: 7409

UniProt: P15498

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, BCR Signaling