VAV1 Antikörper (AA 121-324)
(2 Referenzen)-
- Target Alle VAV1 Antikörper anzeigen
- VAV1 (Vav 1 Oncogene (VAV1))
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Bindungsspezifität
- AA 121-324
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser VAV1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. coli.
- Klon
- 2-00E-11
- Isotyp
- IgG1
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anti-Vav 1 Oncogene (VAV1) (AA 565-795) antibody
VAV1 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (pTyr174) antibodyVAV1 Reaktivität: Human, Ratte, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 681-790) antibodyVAV1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 9C1 unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 681-790) antibodyVAV1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 3A11 unconjugated
anti-Vav 1 Oncogene (VAV1) (N-Term) antibodyVAV1 Reaktivität: Human, Ratte, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (Center) antibodyVAV1 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (Tyr174) antibodyVAV1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 100-200) antibodyVAV1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 426-696) antibodyVAV1 Reaktivität: Human WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (Tyr292) antibodyVAV1 Reaktivität: Human, Ratte, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:250, FCM: 1:200 - 1:400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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: "Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells." in: Cell and tissue research, Vol. 345, Issue 1, pp. 163-75, (2011) (PubMed).
: "The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells." in: Acta pharmacologica Sinica, Vol. 32, Issue 1, pp. 99-107, (2011) (PubMed).
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: "Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells." in: Cell and tissue research, Vol. 345, Issue 1, pp. 163-75, (2011) (PubMed).
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- Target
- VAV1 (Vav 1 Oncogene (VAV1))
- Andere Bezeichnung
- VAV1 (VAV1 Produkte)
- Synonyme
- VAV antikoerper, Vav antikoerper, vav-T antikoerper, vav guanine nucleotide exchange factor 1 antikoerper, vav 1 oncogene antikoerper, vav guanine nucleotide exchange factor 1 L homeolog antikoerper, VAV1 antikoerper, Vav1 antikoerper, vav1.L antikoerper
- Hintergrund
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Description: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Aliases: VAV
- Molekulargewicht
- 98.3 kDa
- Gen-ID
- 7409
- HGNC
- 7409
- Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, BCR Signaling
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