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VAV1 Antikörper (Center)

VAV1 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855640
  • Target Alle VAV1 Antikörper anzeigen
    VAV1 (Vav 1 Oncogene (VAV1))
    Bindungsspezifität
    • 15
    • 11
    • 10
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 69
    • 39
    • 24
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 67
    • 4
    Kaninchen
    Klonalität
    • 67
    • 4
    Polyklonal
    Konjugat
    • 40
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser VAV1 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 34
    • 12
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Maus, Ratte (Rattus), Rind (Kuh)
    Kreuzreaktivität (Details)
    Mouse (92 %), Rat (92 %), Bovine (96 %)
    Produktmerkmale
    Rabbit Polyclonal antibody to VAV1 (vav 1 guanine nucleotide exchange factor)
    VAV1 antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product VAV1 Primärantikörper
  • Applikationshinweise
    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Kommentare

    Positive Control: Molt-4 , Raji , BCL-1

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.33 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    VAV1 (Vav 1 Oncogene (VAV1))
    Andere Bezeichnung
    VAV1 (VAV1 Produkte)
    Hintergrund
    The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

    Molekulargewicht
    98 kDa
    Gen-ID
    7409
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, BCR Signaling
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