VAV1 Antikörper (AA 100-200)

Produktnummer ABIN7271302

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch VAV1 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für VAV1 Antikörper (AA 100-200) (ABIN7271302)

Target: VAV1 (Vav 1 Oncogene (VAV1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VAV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-VAV1 Antikörper

Bindungsspezifität: AA 100-200

Verwendungszweck: VAV1 Rabbit pAb

Sequenz: FDVQDFGKVI YTLSALSWTP IAQNRGIMPF PTEEESVGDE DIYSGLSDQI DDTVEEDEDL YDCVENEEAE GDEIYEDLMR SEPVSMPPKM TEYDKRCCCL R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human VAV1 (NP_005419.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Andere Bezeichnung: VAV1

Hintergrund: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,VAV1,VAV,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Cell differentiation,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,VAV1

Molekulargewicht: 94kDa/98kDa

Gen-ID: 7409

UniProt: P15498

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, BCR Signaling