Rekombinanter Complement Factor B Antikörper

Produktnummer ABIN7490606

Der Human Chimeric anti-Complement Factor B Antikörper wird verwendet zum Nachweis von Complement Factor B in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für Rekombinanter Complement Factor B Antikörper (ABIN7490606)

Target: Complement Factor B (CFB)

Antikörpertyp: Recombinant Antibody

Fragment: Fc fragment

Reaktivität: Human

Wirt: Human, Kaninchen

Klonalität: Chimeric

Konjugat: Dieser Complement Factor B Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: DMC366

Produktdetails anti-Complement Factor B Antikörper

Verwendungszweck: Anti-CFB antibody(DMC366), IgG1 Chimeric mAb

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cyt 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Details zu Complement Factor B

Target: Complement Factor B (CFB)

Andere Bezeichnung: CFB

Hintergrund: AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2
Description: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

UniProt: P00751

Pathways: Komplementsystem, Proton Transport, Ribonucleoside Biosynthetic Process